Global and regional market access, HEOR, medical affairs, and local affiliate teams generate value dossiers, HTA and payer submissions, and local value stories from one governed evidence base — with the version control an MLR team will accept.
Global dossiers, local data, clinical and real-world evidence, and literature live in separate places. Every market request restarts the assembly work, and no two versions agree.
Global and regional market access, HEOR, medical affairs, and local affiliate teams.
The global dossier, regional dossiers, and every local value story are generated from the same Validator Framework instance — a governed digital twin of your evidence, harmonised to one schema with provenance tracked on every claim. Refreshing a market is a re-run against current data, not a re-engagement with a vendor.
Assembled from trials, RWE, and literature with provenance on every claim, then localised per market.
Country templates, budget-impact and cost-effectiveness narratives, reviewer-ready references.
Affiliate-ready narratives and presentations in local format, language, and evidence hierarchy.
Automated systematic review keeps the base current, so a refresh is a re-run rather than a project.
Ask a market access team where their time goes on a new submission and the honest answer is rarely "analysis." It's re-assembly: pulling the same trial data, real-world evidence and literature into a new country template, reformatting citations to the local body's style, and reconciling numbers that quietly drifted between the last two versions of the dossier. See the full teardown in the HTA submission workflow: where teams actually lose time. The judgement calls — which comparator, which endpoint, how to frame the economic argument — are a small fraction of the elapsed time, and they're the part a person should actually be spending their time on.
A governed evidence base attacks the re-assembly, not the judgement. See AI value dossier automation for how dossier generation actually works over that base, and what the review step looks like once a first draft exists.
A dossier is only as good as the evidence underneath it, and clinical and real-world literature doesn't stop accumulating the day a submission is filed. Continuous, automated systematic literature review — screening, extraction, and structured update of a living evidence base — keeps the underlying corpus current without turning every refresh into a fresh research project. See AI for systematic literature review for the honest account of where reviewer judgement stays in that process, because screening and extraction are not the same as deciding what a body of evidence means.
A local value story has to speak the payer's language, follow the local evidence hierarchy, and lead with what that market actually weighs — while never introducing a claim the global dossier doesn't support. That's a narrower task than it sounds: adapting framing and evidence order per market, not generating new arguments per market. See localising payer value stories across markets for how that traceability is maintained when the same core narrative reaches eight different markets in eight different formats.
Medical, legal and regulatory review isn't slowed down by AI-generated content per se — it's slowed down by content it can't trace. Every claim in a generated dossier or value story carries provenance back to its source trial, real-world data point, or literature reference, with version history intact, so a reviewer can approve a specific sentence rather than re-deriving the whole argument from source. This is the same discipline that makes the evidence base reusable market to market: one schema, one provenance trail, regardless of which output it feeds.
A consultancy re-assembles evidence for each market as a fresh project. Eclypse maintains one governed evidence base that dossiers, submissions, and value stories are generated from on demand, so a refresh is a re-run rather than a re-engagement.
Every claim carries provenance back to its source trial, real-world data point, or literature reference, with full version history, specifically so medical, legal, and regulatory review can trace and approve it.
Yes — that is the core pattern. A global value dossier localises into regional and market-specific dossiers and value stories from the same governed base, rather than each market rebuilding from source evidence independently.
Scheduled systematic literature review and data refreshes keep it live, with provenance and version history intact, inside your environment.
Overwhelmingly into re-assembly — pulling the same evidence into a new template and reconciling drift between versions — not into the analytical judgement calls the team is actually there to make.
Only if the process is allowed to introduce claims the global dossier doesn't support. A governed process traces every localised sentence back to an approved source claim.
Our proprietary AI orchestration platform for healthcare: one engine, a registry of reusable task modules and domain agents, and a governed knowledge base — deployed inside your walls and run by your team.